Infants Much Less Likely to Get the Flu if Their Moms Are Vaccinated During Pregnancy

Babies whose moms get flu vaccinations while pregnant have a significantly reduced risk of acquiring influenza during their first six months of life, a new study shows, leading the authors to declare that the need for getting more pregnant women immunised is a public health priority.

In a study published May 3, 2016, in Pediatrics online, University of Utah School of Medicine researchers reported that infants 6 months and younger whose mothers were vaccinated when pregnant had a 70% reduction in laboratory-confirmed flu cases and an 80% reduction in flu-related hospitalisations compared with babies whose moms weren’t immunised. Health records showed that 97% of laboratory-confirmed flu cases occurred in infants whose mom’s were not immunised against the disease while pregnant.

“Babies cannot be immunised during their first six months, so they must rely on others for protection from the flu during that time,” says the study’s lead author, Julie H. Shakib, D.O., M.S., M.P.H., assistant professor of paediatrics. “When pregnant women get the flu vaccine there are clear benefits for their infants.”

Influenza, or the flu, is a nasty bug that causes a variety of symptoms including aches, chills, fevers, nausea and diarrhoea. Illness can last for a week or longer and results in about 30,000 deaths each year in the U.S; pregnant women and young infants are among those at highest risk for dying from flu. Maternal-foetal medicine specialist Michael W. Varner, M.D., professor and vice chair for research in the Department of Obstetrics and Gynecology and a co-author on the study says pregnant women are not at greater risk for getting the flu, but because of changes that occur to their bodies during pregnancy, are more likely to be severely affected.

Shakib and colleagues examined more than 245,000 de-identified health records of pregnant women and more than 249,000 infant records for nine flu seasons from December 2005 through March 2014. (The number of infant births included twins, triplets or even larger sets of babies, which accounts for the total number of infant birth records being greater than the number of records of pregnant women.) Approximately 10% of the women – 23,383 – reported being vaccinated while pregnant compared with 222,003 who said they were not vaccinated.

The difference between the two groups in the number of laboratory-confirmed influenza cases and influenza hospitalisations within six months of birth was stark, the researchers found. Among 658 infants identified with laboratory-confirmed influenza, 638 cases – 97% – occurred in babies whose moms were not immunised. A total of 151 of the 658 infants were hospitalised, with148 being born to non-immunised pregnant women.

To see whether the benefits observed in infants born to mothers who received flu vaccinations were not related to chance, the researchers also examined health records for the incidence of RSV (respiratory syncytial virus), a respiratory infection that also occurs in infants and young children during the winter months. The analysis found that the vaccine had no effect on the incidence of RSV among infants, strengthening the findings that the benefits seen in the infants were actually due to the flu vaccine their mothers received.

Although the vaccination rate among pregnant women increased in the past couple of years, it’s still not high enough, according to infectious diseases expert Carrie L. Byington, M.D., senior author on the study, professor of paediatrics and co-director of the Center for Clinical and Translational Science (CCTS) at the University of Utah Health Sciences, which provided support for the study.

“This is a public health issue,” says Byington, also U of U Health Sciences associate vice president for faculty and academic affairs and H.A. and Edna Benning Presidential Endowed Chair in paediatrics. “About 50% of pregnant women reported being immunised in the latest flu season. But we need to get that number much closer to 100%.”

Vaccination rates in pregnant women averaged 10% over the course of the nine flue seasons studied. However, between June 2009 and September 2010, when the spread of the H1N1 flu reached pandemic levels worldwide, vaccination rates increased significantly as people became more aware of the risks of flu for pregnant women and their infants. “Pregnant women are a high-risk group during influenza season and influenza outbreaks and should receive vaccinations,” Varner says. “If their caregivers don’t offer them influenza vaccinations, I would encourage all pregnant women to ask them for it.”

Obstetricians and paediatricians have worked closer in recent years to increase flu vaccinations in pregnant women, and Byington and Shakib want to see more collaboration between the two types of doctors.

“We just really hope more pregnant women get the vaccine,” Shakib says. “That’s the take-home message of the study.”

(Source: University of Utah, Pediatrics)