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Scientists Dr Anne Hinks, Dr Joanna Cobb and Professor Wendy Thomson, from the University’s Arthritis Research UK Epidemiology Unit, whose work is published in Nature Genetics, looked at DNA extracted from blood and saliva samples of 2,000 children with childhood arthritis and compared these to healthy people.
Principal Investigator Professor Thomson, who also leads the Inflammatory Arthritis in Children theme at the National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, said: “This study brought together an international group of scientists from around the world and is the largest investigation into the genetics of childhood arthritis to date. The success was, in large part, due to it being an international effort with collaborators with Cincinnati Childrens Hospital (Professor Sue Thompson), Wake Forest School of Medicine (Professor Carl Langefeld) and Emory University School of Medicine (Professor Sampath Prahalad).”
Childhood arthritis affects one in 1,000 in the UK. It is caused by a combination of genetic and environmental risk factors, however until recently very little was known about the genes that are important in developing this disease – only three were previously known.
Dr Hinks, joint lead author of the study, said the findings were a significant breakthrough for understanding more about the biology of the disease and this might help identify novel therapies for the disease. “Childhood arthritis, also known as juvenile idiopathic arthritis (JIA), is a specific type of arthritis quite separate from types found in adults and there’s been only a limited amount of research into this area in the past,” she said. “This study set out to look for specific risk factors. To identify these 14 genetic risk factors is quite a big breakthrough. It will help us to understand what’s causing the condition, how it progresses and then to potentially develop new therapies.”
The study may help to predict which children need specific treatment earlier and allow health workers to better control their pain management, quality of life and long-term outcome. Currently 30 per cent of children with the disease continue to suffer from arthritis in adulthood.
Dr Cobb, joint lead author, added: “There are lots of different forms of childhood arthritis so identifying the markers will help us understand a little bit more about the disease process. It will also help to categorise children with JIA into sub-types dependent on which genes they have and allow us to determine the best course of treatment.”
The study which took two years to complete, will ultimately help clinicians to better manage children with the disease and give potential to develop new therapies.
Source: The University of Manchester
